Estrogen Reduces Breast Cancer Stem Cells and Aggression in Breast Cancer, Study Suggests
A team of researchers at CIC bioGUNE has revealed that estrogen can reduce the risk of breast cancer. Their work shows that estrogen is capable of reducing the number of breast cancer stem cells, which may explain the lower aggression of the tumor and, as a consequence, the possibility of a better prognosis.
The project was published in Breast Cancer Research and Treatment and the team will present the results at the International Conference on Breast Cancer to be held in Madrid. The research combined the use of human samples and laboratory cell lines.
The identification of cancer stem cells (or tumor-initiating cells) has opened up a new perspective on breast cancer, with new hopes for treatment in the future. To date treatment against cancer was designed to reduce the mass of the tumour. Nevertheless, what has recently been discovered is that, while traditional treatment is capable of killing most of the cell mass of the tumor, the cancer stem cells are more resistant to common treatment such as chemotherapy and radiation. Thus, in order to cure the cancer with greater efficacy and definitively, it is important to find ways to eliminate cancer stem cells as well.
Estrogen is a hormone which is not without its complexity; on the one hand it is essential for the normal development and functioning of the breast and, on the other, this same hormone induces the proliferation of cancer cells once the breast tumor has appeared, i.e. estrogen is also a risk factor in breast cancer. However, nothing or little has been known until now about the effect of estrogen on the tumor-initiating cells...
Exposure to Young Triggers New Neuron Creation in Females Exhibiting Maternal Behavior
Maternal behavior itself can trigger the development of new neurons in the maternal brain independent of whether the female was pregnant or has nursed, according to a study released by researchers at Tufts University's Cummings School of Veterinary Medicine. These findings performed in adult, virgin rats were published in Brain Research Bulletin.
In the study, virgin, or nulliparous, rats were exposed to foster pups each day until they began to exhibit maternal behavior, including crouching over the young, grouping them, or retrieving them back to the nest. Data from the study showed that the nulliparous rats exposed to pups have increased numbers of new neurons.
The research was undertaken by Cummings School Department of Biomedical Sciences researchers Miyako Furuta and Robert Bridges, who is the head of the Cummings School's reproduction and neurobiology section...
Mass Reef Spawning Could Be Triggered By Twilight
Reproduction can be a haphazard event, especially when you simply cast your gametes into the sea and hope for the best. However, some organisms in coral reefs have improved their odds by synchronising when they spawn. These mass spawning events on reefs can last for as little as 20 min and only occur during twilight for a few nights each year. So, how do animals that lack even the simplest of nervous systems coordinate such sophisticated behaviour? Alison Sweeney and her colleagues from the University of California, Santa Barbara, and Duke University wondered whether mass spawning events might be synchronised by fluctuations in the twilight spectrum. They explain that the spectrum of twilight is deep blue before the moon rises, but after moonrise the spectrum becomes redder. As the moon is already in the sky at sunset during the first half of a lunar month, the twilight spectrum is always red shifted, but at full moon (when the moon is just below the horizon at sunset) there is a brief period when the spectrum of skylight is deep twilight blue before the moon rises. Sweeney and her colleagues realised that corals and other reef residents could use this brief period of pure twilight to synchronise spawning, but only if the spectrum of light in the ocean followed the same pattern as skylight.
Measuring the spectrum of light in the ocean above a coral reef in the US Virgin Islands over a 6 day period around full moon, the team found that the twilight spectrum shifted significantly depending on whether or not the moon had risen. At full moon, the twilight spectrum was deep blue just after sunset but gained red wavelengths as soon as the moon rose. Also, the length of the blue twilight period increased on subsequent evenings as the moon rose later each day. While recording the light spectrum, the team also monitored elkhorn coral colonies for spawning events and found that the corals spawned simultaneously between 21:30 h and 21:50 h on the third and fourth nights after the full moon...
Obesity Has Doubled Since 1980, Major Global Analysis of Risk Factors Reveals
The worldwide prevalence of obesity has nearly doubled since 1980, according to a major study on how three important heart disease risk factors have changed across the world over the last three decades. The study, published February 4 in three papers in the Lancet, looked at all available global data to assess how body mass index, blood pressure and cholesterol changed between 1980 and 2008.
The study shows that in 2008, more than one in ten of the world's adult population was obese, with women more likely to be obese than men. An estimated 205 million men and 297 million adult women were obese -- a total of more than half a billion adults worldwide.
The proportion of the world's population with high blood pressure, or uncontrolled hypertension, fell modestly between 1980 and 2008. However, because of population growth and ageing, the number of people with uncontrolled hypertension rose from 600 million in 1980 to nearly 1 billion in 2008. High-income countries achieved large reductions in uncontrolled hypertension, with the most impressive progress seen in women in Australasia and men in North America. Uncontrolled hypertension is defined as a systolic blood pressure higher than 140 mmHg or diastolic blood pressure higher than 90 mmHg...
The Wiley Protocol Is Now Patent Protected
Ten years after the first in lab experiments with 
progesterone and breast cancer cells, seven years after the publication of Sex, Lies and Menopause and the creation of the Wiley Protocol for women, the USPTO has recognized the Wiley Protocol as unique with its recent patent ruling : The Wiley Protocol # 7,879,830.
Patented for treatment using a 28-day biomimetic, variable dose cycling bio-identical hormone therapy protocol, this ground-breaking ruling paves the way for greater standardization of compounded medicines, including standardized dose modification, which increases safety for women, and complete protection for patients who wish to utilize WP for therapy. They can now be assured they are getting the real Protocol made by trained pharmacists and dispensed by knowledgeable physicians.
It's a nod toward the unique nature, long term clinical results, and peer-reviewed science driven approach that the Wiley Protocol entails. We will continue to study BHRT in this now patent-protected environment for the good of all women. Physicians and Pharmacists who join our project can, too, now be assured of governmental co-operation to produce quantity medical care....
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